The paper assesses regional differences in the interactions between the natural and organisational factors in Polish agriculture. The analysis carried out in the dynamic approach covers the 2002-2013 period, and the indicators for individual voivodeships are compared to the average for Poland as a reference system. The research, in addition to descriptive statistics, uses also grouping of voivodeships with the use of cluster analysis with method of k-means. Conducted research indicates that the direction and strength of the interaction of selected environmental and organisational factors is differentiated between Polish regions. The observed nationwide trends and interdependencies of analysed natural and organisational factors do not reflect properly the scale and effects of changes in different regions of the country. Because of the multifactor determinants of agricultural production, consequences of their impact on the regions are highly different. This is manifested by realization, in various parts of Poland, of different models of agricultural production, which are characterised by different levels of organisation and intensity. The analysis indicates the need for regionalisation of national agricultural policy, including the Rural Development Programme. This approach should contribute to more effective spending of funds addressed to agriculture and rural areas by optimising the process of their development.